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1

N -(3-Acyloxy-2-benzylpropyl)- N ‘-[4-(methylsulfonylamino)benzyl]thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor

Lee, Jeewoo, Lee, Jiyoun, Kang, Myungshim, Shin, Myoungyoup, Kim, Ji-Min, Kang, Sang-Uk, Lim, Ju-Ok, Choi, Hyun-Kyung, Suh, Young-Ger, Park, Hyeung-Geun, Oh, Uhtaek, Kim, Hee-Doo, Park, Young-Ho, Ha,

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 184 KB

english, 2003

2

Secure and reliable blockchain-based eBook transaction systemÂ for self-published eBook trading

Chi, Jeonghee, Lee, Jangyeon, Kim, Nakyung, Choi, Jeewoo, Park, Soyoung, Debiao, He

Journal:

Année:

2020

Langue:

english

Fichier:

PDF, 4.22 MB

english, 2020

3

Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin

Kyung-Soo Chun, Yeowon Sohn, Ho-Shik Kim, Ok Hee Kim, Kwang-Kyun Park, Jong-Min Lee, Jeewoo Lee, Ji-Youn Lee, Aree Moon, Sang Sup Lee, Young-Joon Surh

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1999

Langue:

english

Fichier:

PDF, 179 KB

english, 1999

4

Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities

Duan, Dehui, Sigano, Dina M., Kelley, James A., Lai, Christopher C., Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Lee, Jeewoo, Abeyweera, Thushara P., Rotenberg, Susan A., Kim, Hee, Kim, Young Ho,

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 3.49 MB

english, 2008

5

Facile Synthesis of Fluorescent Polymer Nanoparticles by Covalent Modification-Nanoprecipitation of Amine-Reactive Ester Polymers

Lee, Yeonju, Hanif, Sadaf, Theato, Patrick, Zentel, Rudolf, Lim, Jeewoo, Char, Kookheon

Journal:

Macromolecular Rapid Communications

Année:

2015

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2015

6

α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine Releasing Protein 3 (RasGRP3) Ligands

Ann, Jihyae, Czikora, Agnes, Saini, Amandeep, Zhou, Xiaoling, Mitchell, Gary A., Lewin, Nancy E., Peach, Megan L, Blumberg, Peter M., Lee, Jeewoo

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 953 KB

english, 2018

7

ChemInform Abstract: Methionine Analogues as Inhibitors of Methionyl-tRNA Synthetase.

Jeewoo Lee, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kwak, Sunghoon Kim

Journal:

Année:

1999

Fichier:

PDF, 27 KB

1999

8

ChemInform Abstract: Methionyl Adenylate Analogues as Inhibitors of Methionyl-tRNA Synthetase.

Jeewoo Lee, Sang Uk Kang, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kwak, Sunghoon Kim

Journal:

Année:

1999

Fichier:

PDF, 28 KB

1999

9

ChemInform Abstract: A Facile and Practical Synthesis of Capsazepine, a Vanilloid Receptor Antagonist.

Jeewoo Lee, Jiyoun Lee

Journal:

Année:

2000

Fichier:

PDF, 29 KB

2000

10

ChemInform Abstract: 3-Acyloxy-2-phenalkylpropyl Amides and Esters of Homovanillic Acid as Novel Vanilloid Receptor Agonists.

Jeewoo Lee, et al. et al.

Journal:

Année:

2000

Fichier:

PDF, 26 KB

2000

11

ChemInform Abstract: 5-Acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a Novel Template for Protein Kinase C (PKC) Binding.

Jeewoo Lee, Kee-Chung Han, Sang-Yoon Lee, Su-Yeon Kim, Ji-Hye Kang, Nancy E. Lewin, Lionel S. Best, Peter M. Blumberg, Victor E. Marquez

Journal:

Année:

2001

Fichier:

PDF, 33 KB

2001

12

ChemInform Abstract: Vanilloid and Isovanilloid Analogues as Inhibitors of Methionyl-tRNA and Isoleucyl-tRNA Synthetases.

Jeewoo Lee, Sang Uk Kang, Su Yeon Kim, Sung Eun Kim, Yeong Joon Jo, Sunghoon Kim

Journal:

Année:

2001

Fichier:

PDF, 36 KB

2001

13

ChemInform Abstract: Ester and Hydroxamate Analogues of Methionyl and Isoleucyl Adenylates as Inhibitors of Methionyl-tRNA and Isoleucyl-tRNA Synthetases.

Jeewoo Lee, Sang Uk Kang, Su Yeon Kim, Sung Eun Kim, Mee Kyoung Kang, Yeong Joon Jo, Sunghoon Kim

Journal:

Année:

2001

Fichier:

PDF, 33 KB

2001

14

ChemInform Abstract: Phenolic Modification as an Approach to Improve the Pharmacology of the 3-Acyloxy-2-benzylpropyl Homovanillic Amides and Thioureas, a Promising Class of Vanilloid Receptor Agonists and Analgesics.

Jeewoo Lee, Jiyoun Lee, Myung-Sim Kang, Kang-Pil Kim, Suk-Jae Chung, Peter M. Blumberg, Jung-Bum Yi, Young Ho Park

Journal:

Année:

2002

Fichier:

PDF, 26 KB

2002

15

Deoxyribosyl Analogues of Methionyl and Isoleucyl Sulfamate Adenylates as Inhibitors of Methionyl-tRNA and Isoleucyl-tRNA Synthetases.

Sung Eun Kim, Su Yeon Kim, Sunghoon Kim, Taehee Kang, Jeewoo Lee

Journal:

Année:

2005

Fichier:

PDF, 14 KB

2005

16

ChemInform Abstract: Polar 3-Alkylidene-5-pivaloyloxymethyl-5′-hydroxymethyl-γ-lactones as Protein Kinase C Ligands and Antitumor Agents.

Jeewoo Lee, et al. et al.

Journal:

Année:

2010

Fichier:

PDF, 81 KB

2010

17

Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells

Christopher A. Reilly, Mark E. Johansen, Diane L. Lanza, Jeewoo Lee, Ju-Ok Lim, Garold S. Yost

Journal:

Journal of Biochemical and Molecular Toxicology

Année:

2005

Langue:

english

Fichier:

PDF, 184 KB

english, 2005

18

3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors

Su Yeon Kim, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 406 KB

english, 2003

19

N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’

Jeewoo Lee, Sang-Uk Kang, Ju-Ok Lim, Hyun-Kyung Choi, Mi-kyung Jin, Attila Toth, Larry V Pearce, Richard Tran, Yun Wang, Tamas Szabo, Peter M Blumberg

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 430 KB

english, 2004

20

Structure–activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding

Jeewoo Lee, Su Yeon Kim, Soyoung Park, Ju-Ok Lim, Ji-Min Kim, Myungshim Kang, Jiyoun Lee, Sang-Uk Kang, Hyun-Kyung Choi, Mi-Kyung Jin, Jacqueline D Welter, Tamas Szabo, Richard Tran, Larry V Pearce, A

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 467 KB

english, 2004

21

3D-QSAR analysis of conformationally constrained diacylglycerol (DAG) analogues as potent protein kinase C (PK-C) ligands

Su Yeon Kim, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 304 KB

english, 2004

22

Analysis of structure–activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism

Jeewoo Lee, Su Yeon Kim, Jiyoun Lee, Myungsim Kang, Min-Jung Kil, Hyun-Kyung Choi, Mi-Kyung Jin, Yun Wang, Attila Toth, Larry V Pearce, Daniel J Lundberg, Richard Tran, Peter M Blumberg

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 382 KB

english, 2004

23

Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging

Seung-Jun Oh, Kyo Chul Lee, Sang-Yoon Lee, Eun Kyoung Ryu, Hideo Saji, Yearn Seong Choe, Dae Yoon Chi, Sang Eun Kim, Jeewoo Lee, Byung-Tae Kim

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 373 KB

english, 2004

24

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands

Jeewoo Lee, Ju-Hyun Lee, Su Yeon Kim, Nicholas A. Perry, Nancy E. Lewin, Jolene A. Ayres, Peter M. Blumberg

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 254 KB

english, 2006

25

Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Farhanullah, Su Yeon Kim, Eun-Jeong Yoon, Eung-Chil Choi, Sunghoon Kim, Taehee Kang, Farhana Samrin, Sadhna Puri, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 195 KB

english, 2006

26

Polar 3-alkylidene-5-pivaloyloxymethyl-5′-hydroxymethyl-γ-lactones as protein kinase C ligands and antitumor agents

Ji-Hye Kang, Yerim Kim, Shin-Hye Won, Song-Kyu Park, Chang Woo Lee, Hwan-Mook Kim, Nancy E. Lewin, Nicholas A. Perry, Larry V. Pearce, Daniel J. Lundberg, Robert J. Surawski, Peter M. Blumberg, Jeewoo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 286 KB

english, 2010

27

Design and synthesis of heterocyclic analogues of mycophenolic acid as potential chemotherapeutic agents

Jeewoo Lee, Wayne K. Anderson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 271 KB

english, 1995

28

Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptor

Jeewoo Lee, Geza Acs, Peter M. Blumberg, Victor E. Marquez

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 189 KB

english, 1995

29

Synthesis of bis-γ-butyrolactones containing conformationally constrained (S)- and (R)-diacylglycerol structures

Jeewoo Lee, Nancy E. Lewin, Peter M. Blumberg, Victor E. Marquez

Journal:

Bioorganic & Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 627 KB

english, 1996

30

α-Substituted N-(4-tert-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists

Jae-Uk Chung, Su Yeon Kim, Ju-Ok Lim, Hyun-Kyung Choi, Sang-Uk Kang, Hae-Seok Yoon, HyungChul Ryu, Dong Wook Kang, Jeewoo Lee, Bomi Kang, Sun Choi, Attila Toth, Larry V. Pearce, Vladimir A. Pavlyukove

Journal:

Bioorganic & Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 384 KB

english, 2007

31

Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin

Dong Wook Kang, Yong Soo Kim, Kwang Su Lim, Myeong Seop Kim, Larry V. Pearce, Vladimir A. Pavlyukovets, Andy K. Tao, Krystle A. Lang-Kuhs, Peter M. Blumberg, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 826 KB

english, 2010

32

Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects

Young-Ger Suh, Yong-Sil Lee, Kyung-Hoon Min, Ok-Hui Park, Ho-Sun Seung, Hee-Doo Kim, Hyoung-Geun Park, Ji-Yeon Choi, Jeewoo Lee, Sang-Wook Kang, Uh-taek Oh, Jae-yeon Koo, Yung-Hyup Joo, Sun-Young Kim,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 199 KB

english, 2003

33

N-4-Substituted-benzyl-N′-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity

Hyeung-geun Park, Ji-yeon Choi, Sea-hoon Choi, Mi-kyung Park, Jihye Lee, Young-ger Suh, Hawon Cho, Uhtaek Oh, Jiyoun Lee, Sang-Uk Kang, Jeewoo Lee, Hee-Doo Kim, Young-Ho Park, Yeon Su Jeong, Jin Kyu C

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 208 KB

english, 2004

34

Synthesis of 7′-[123I]iodo-d-luciferin for in vivo studies of firefly luciferase gene expression

Sang-Yoon Lee, Yearn Seong Choe, Kyung-Han Lee, Jeewoo Lee, Yong Choi, Byung-Tae Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 127 KB

english, 2004

35

Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

Sung Eun Kim, Su Yeon Kim, Sunghoon Kim, Taehee Kang, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 325 KB

english, 2005

36

Analysis of structure–activity relationships for the ‘B-region’ of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists

Jeewoo Lee, Mi-Kyoung Jin, Sang-Uk Kang, Su Yeon Kim, Jiyoun Lee, Myoungyoup Shin, Jaemin Hwang, Sookhyun Cho, Yeon-Sil Choi, Hyun-Kyung Choi, Sung-Eun Kim, Young-Ger Suh, Yong-Sil Lee, Young-Ho Kim,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 2.34 MB

english, 2005

37

Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors

Su Yeon Kim, Yeon-Sook Lee, Taehee Kang, Sunghoon Kim, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 227 KB

english, 2006

38

Receptor activity and conformational analysis of 5′-halogenated resiniferatoxin analogs as TRPV1 ligands

Kwang Su Lim, Dong Wook Kang, Yong Soo Kim, Myeong Seop Kim, Seul-Gi Park, Sun Choi, Larry V. Pearce, Peter M. Blumberg, Jeewoo Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 705 KB

english, 2011

39

Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands

Jeewoo Lee, Su Yeon Kim, Ji-Hye Kang, Geza Acs, Peter Acs, Peter M Blumberg, Victor E Marquez

Journal:

European Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 285 KB

english, 2004

40

Conformationally constrained analogues of N′-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists

Ju-Ok Lim, Mi-Kyoung Jin, HyungChul Ryu, Dong Wook Kang, Jeewoo Lee, Larry V. Pearce, Richard Tran, Attila Toth, Peter M. Blumberg

Journal:

European Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 337 KB

english, 2009

41

2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors

Farhanullah, Taehee Kang, Eun-Jung Yoon, Eun-Chil Choi, Sunghoon Kim, Jeewoo Lee

Journal:

European Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 658 KB

english, 2009

42

Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity

Kassoum Nacro, Jeewoo Lee, Joseph J Barchi Jr., Nancy E Lewin, Peter M Blumberg, Victor E Marquez

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 221 KB

english, 2002

43

Synthesis of two rigid diacylglycerol analogues having a perhydro furo[34-b]furan bis-γ-butyrolactone skeleton. 2.

Jeewoo Lee, Victor E. Marquez, Nancy E. Lewin, Peter M. Blumberg

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 237 KB

english, 1993

44

Synthesis of two rigid diacylglycerol analogues having a bis-butyrolactone skeleton

Jeewoo Lee, Kelly Teng, Victor E. Marquez

Journal:

Tetrahedron Letters

Année:

1992

Langue:

english

Fichier:

PDF, 266 KB

english, 1992

45

A comparative study of quantitative structure activity relationship methods based on antitumor diarylsulfonylureas

Hea-Young Park Choo, Jae-Su Lim, Yurim Kam, Su Yeon Kim, Jeewoo Lee

Journal:

European Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 220 KB

english, 2001

46

Conformationally constrained analogues of diacylglycerol (DAG). 3. Interaction of α-alkyl-γ-lactones with protein kinase C (PK-C)

Jeewoo Lee, Victor E. Marquez, Nancy E. Lewin, Marcelo G. Kazanietz, Afshin Bahador, Peter M. Blumberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 367 KB

english, 1993

47

Conformationally constrained analogues of diacylglycerol (DAG). 4. Interaction of α-alkylidene-γ-lactones with protein kinase C (PK-C)

Jeewoo Lee, Victor E. Marquez, Nancy E. Lewin, Afshin Bahador, Marcelo G. Kazanietz, Peter M. Blumberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 252 KB

english, 1993

48

Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

Jeewoo Lee, Sang Uk Kang, Su Yeon Kim, Sung Eun Kim, Mee Kyoung Kang, Yeong Joon Jo, Sunghoon Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 282 KB

english, 2001

49

Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

Jeewoo Lee, Sang Uk Kang, Su Yeon Kim, Sung Eun Kim, Yeong Joon Jo, Sunghoon Kim

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 257 KB

english, 2001

50

Conformationally constrained analogues of diacylglycerol. 6. Changes in PK-C binding affinity for 3-O-acyl-2-deoxy-L-ribonolactones bearing different acyl chains.

Victor E. Marquez, Jeewoo Lee, Rajiv Sharma, Kelly Teng, Shaomeng Wang, Nancy E. Lewin, Afshin Bahador, Marcelo G. Kazanietz, Peter M. Blumberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 393 KB

english, 1994